Salmonellosis causes significant economic losses due to mass abortions, infertility, and culling of productive animals in many countries, including Azerbaijan. Regardless of the fact of using prevention strategies in order to protect human health salmonellosis still remains one of the major food-borne diseases.
            The aim of the investigation is to determine the prevalence of salmonellosis in Azerbaijan. The study was carried out in 2020-2021 and covered all regions of Azerbaijan. Laboratories reports (Central Veterinary Laboratory, National Reference Laboratory, and Regional Laboratories) which were conducted by testing of Salmonella spp. in foods (plant and animal source) and in pathology material of domestic animals (cattle/small ruminants/poultry) were analyzed. Salmonella spp. in the food samples was detected according to the method for the detection of Salmonella spp. in food products (ISO 6579-1:2017). Diagnostics of Salmonellosis in the pathology material of domestic animals was conducted by the bacteriological method. The results were confirmed biochemically and serologically.  
            During the investigation, 690 samples of domestic animals’ pathology material were tested and 15 (2.2%) samples were positive for Salmonella spp. As well, the number of tested foods samples were 28.857, 78 of them (0.27%) were confirmed as positive for Salmonella spp. The majority of samples that were positive were detected in 2021, respectively as 11 in pathology material and 52 in food samples were registered. In 2020, these numbers were 4 for pathological material and 26 for food samples.
Visible increase in Salmonellosis cases detected in 2021 is related to using more sensitive techniques such as RT-PCR for the detection of Salmonella spp. It is also important to test water, and feed samples from all regions of Azerbaijan regularly to conduct the risk assessment for Salmonella species for ensuring food safety and controlling public health.